Burden of Human papillomavirus (HPV)-related disease and potential impact of HPV vaccines in the Republic of Korea

Autor: Francesc Bosch, Laia Bruni, Jin-Kyoung Oh, Hyunju Lee, Crystal Freeman, Young-Tak Kim, Laia Alemany, Beatriz Serrano, Shin-Wha Lee, Jae Kwan Lee
Rok vydání: 2019
Předmět:
Male
Oncology
Papillomavirus vaccines
Vacuna del papil·lomavirus
Uterine Cervical Neoplasms
Disease
0302 clinical medicine
Cost of Illness
Cervix cancer
Cervical cancer screening
030212 general & internal medicine
Young adult
Child
Papillomaviridae
Cancer
Aged
80 and over
Cervical cancer
education.field_of_study
virus diseases
Middle Aged
female genital diseases and pregnancy complications
Infectious Diseases
030220 oncology & carcinogenesis
Cohort
Female
Adult
Human papillomavirus
Papillomavirus vaccine
medicine.medical_specialty
Adolescent
Càncer de coll uterí
Papillomaviruses
Population
Burden
HPV vaccines
Article
lcsh:Infectious and parasitic diseases
Young Adult
03 medical and health sciences
Virology
Internal medicine
Republic of Korea
medicine
Humans
lcsh:RC109-216
Papillomavirus Vaccines
Papil·lomavirus
education
Disease burden
Aged
business.industry
Papillomavirus Infections
medicine.disease
business
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
Papillomavirus Research
Papillomavirus Research, Vol 7, Iss, Pp 26-42 (2019)
ISSN: 2405-8521
DOI: 10.1016/j.pvr.2018.12.002
Popis: Background We aimed to review the burden and the potential impact of human papillomavirus (HPV) vaccines on HPV-related diseases in the Republic of Korea and to discuss cervical cancer prevention practices in this country. Methods Cancer burden statistics were retrieved from GLOBOCAN-2018 and Statistics Korea. HPV disease burden was assessed via systematic review. Vaccine types relative contribution (RC) was estimated using data from an international project using formalin-fixed paraffin-embedded specimens. Results Despite a downtrend in cervical cancer in recent years, Korean rates remain high. In contrast, oropharyngeal cancer incidence has gradually increased and other anogenital cancers remain rare. In Korea, HPV prevalence in general population is around 20%. In cervical cancer, RC of HPVs 16/18 (74.0%) increased to 92.0% when including HPVs 31/33/45/52/58. Limited information was available for other HPV-related cancer sites. Regarding prevention, since the inclusion of the HPV vaccine into the National Immunization Program, almost half (49%) of the target cohort in 2016 had received the first dose of vaccine. Further, percentage of women screened with pap has increased from 41.1%-2009 to 53.0%-2016. Conclusions HPV-related disease burden in Korea is significant. Results suggest that the combination of effective and high coverage HPV vaccination and screening programmes could substantially impact on HPV-related disease in Korea.
Highlights • HPV-related disease burden (cancer and genital warts) in Korea is significant. • HPV16 is the most frequent genotype, causing itself more than 60% of HPV-related cancers. • HPV vaccine types 16/18/31/33/45/52/58/6/11 cause 92.0% of cervical cancers. • HPV vaccines could significantly impact on the HPV-related disease burden.
Databáze: OpenAIRE
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