Interaction of engineered nanomaterials with the immune system: Health-related safety and possible benefits
| Autor: | Boraschi, B.J. Swartzwelter, P. Italiani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Innate immune system Computer science Engineered nanomaterials Health related Toxicology nanomedicine 3. Good health engineered nanomaterials 03 medical and health sciences 030104 developmental biology Immune system Risk analysis (engineering) inflammation Curing diseases nanotoxicology Nanocarriers immunosafety innate immunity |
| Zdroj: | Current opinion (New York, N.Y.) (2018). doi:10.1016/j.cotox.2018.02.002 info:cnr-pdr/source/autori:Boraschi, D., B.J. Swartzwelter, and P. Italiani/titolo:Interaction of engineered nanomaterials with the immune system: health related safety and possible benefits./doi:10.1016%2Fj.cotox.2018.02.002/rivista:Current opinion (New York, N.Y.)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume Current Opinion in Toxicology |
| ISSN: | 2468-2020 |
| DOI: | 10.1016/j.cotox.2018.02.002 |
| Popis: | Understanding the mechanisms of interaction between nanomaterials and the immune system will provide us with endless possibilities of exploiting nano-objects for tuning immune responses towards preventing or curing diseases. We propose here strategies and actions that could help us in strengthening and exploiting such knowledge. By varying their composition, size, shape, and surface properties, it is possible to obtain a vast range of nanocarriers to target specific organs, tissues or cells for diagnostic, preventive and therapeutic purposes. Also, evaluation of immunosafety of such nanomaterials will contribute to designing nanomedical products devoid of side effects. In this review, we will describe the interaction of nanoparticles with the systemic and tissue-specific immune system, with a particular focus on innate immunity, aiming at providing information on the state-of-the art of nano-immune interactions and perspectives about future possibilities of exploitation. |
| Databáze: | OpenAIRE |
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