Haemodynamic effects of diaspirin crosslinked haemoglobin (DCLHb) given before abdominal aortic aneurysm surgery
| Autor: | J.A.W. Wildsmith, M. A. Garrioch, J.H. Mcclure |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Mean arterial pressure medicine.medical_specialty Cardiac index Hemodynamics Blood Pressure Hemoglobins Oxygen Consumption Blood Substitutes Heart Rate medicine.artery Infusion Procedure Preoperative Care medicine Humans Single-Blind Method Radial artery Aged Aged 80 and over Aorta Aspirin business.industry Abdominal aorta Middle Aged medicine.disease Abdominal aortic aneurysm Surgery Anesthesiology and Pain Medicine Vasoconstriction Anesthesia Female business Aortic Aneurysm Abdominal |
| Zdroj: | British journal of anaesthesia. 83(5) |
| ISSN: | 0007-0912 |
| Popis: | We studied 34 patients undergoing elective repair of an abdominal aortic aneurysm under combined general anaesthesia and epidural block to evaluate the acute effects of diaspirin crosslinked haemoglobin (DCLHb) 50, 100 and 200 mg kg-1 i.v. Haemodynamic variables were measured continuously using pulmonary and radial artery catheters, and oxygen delivery and consumption were calculated at regular intervals. DCLHb was shown to be vasoactive, producing an increase in mean arterial pressure of approximately 25% with each dose, with small decreases in cardiac index and calculated oxygen delivery. These effects persisted beyond the end of infusion and provided a degree of cardiovascular stability during the operative procedure. The effects of DCLHb on oxygen consumption at these doses were minimal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|