Effective anti-tuberculosis therapy correlates with plasma small RNA
| Autor: | Alexander Pym, Stephen H. Gillespie, Dimitrios Evangelopoulos, Isobella Honeyborne, Marc Lipman, Timothy D. McHugh, Clare Eckold |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Small RNA Tuberculosis Sample processing Antitubercular Agents HIV Infections Disease Anti tuberculosis microRNA Isoniazid Medicine Humans Prospective Studies Tuberculosis Pulmonary business.industry Coinfection Gene Expression Profiling Respiratory disease medicine.disease Pyrazinamide Clinical microbiology MicroRNAs Treatment Outcome Immunology RNA Female Rifampin business Biomarkers Ethambutol |
| Zdroj: | The European respiratory journal. 45(6) |
| ISSN: | 1399-3003 |
| Popis: | Small RNA (smRNA) is a diverse family of translation regulation molecules, which includes microRNA (miRNA). Changes in miRNA have been reported in association with respiratory disease [1] and in mycobacterial infection [2]. Studies have measured concentrations of miRNA pooled from multiple subjects with active tuberculosis (TB) disease compared with latently infected individuals and healthy controls [3]. However, this approach cannot assess variation between individuals, nor does it describe changes that might occur with treatment, both of which may be helpful in characterising and predicting patient outcome. Plasma small RNA concentration declines in response to anti-tuberculosis therapy and is independent of HIV-status We would like to thank S. Bokhari and S. Christou (Centre for Clinical Microbiology, Dept of Infection, University College London, London, UK) for assistance with sample processing and C. Smith (Research Dept of Infection and Population Health, University College London, London, UK) for statistical support. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|