Anticoagulant treatment satisfaction with warfarin and direct oral anticoagulants for venous thromboembolism
Autor: | Dongjie Fan, Cecilia Portugal, Margaret C. Fang, Alan S. Go, Sue Hee Sung, Priya A. Prasad, Jin-Wen Hsu, Kristi Reynolds |
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Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Patient demographics Administration Oral Personal Satisfaction 030204 cardiovascular system & hematology Article Direct oral anticoagulants Treatment satisfaction 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aged Retrospective Studies Multivariable linear regression business.industry Warfarin Anticoagulants Treatment options Venous Thromboembolism Hematology Anticoagulant therapy Cohort Female Cardiology and Cardiovascular Medicine business Venous thromboembolism medicine.drug |
Zdroj: | Journal of Thrombosis and Thrombolysis, vol 52, iss 4 Journal of Thrombosis and Thrombolysis |
ISSN: | 1573-742X 0929-5305 |
DOI: | 10.1007/s11239-021-02437-z |
Popis: | Treatment options for patients with venous thromboembolism (VTE) include warfarin and direct oral anticoagulants (DOACs). Although DOACs are easier to administer than warfarin and do not require routine laboratory monitoring, few studies have directly assessed whether patients are more satisfied with DOACs. We surveyed adults from two large integrated health systems taking DOACs or warfarin for incident VTE occurring between January 1, 2015 and June 30, 2018. Treatment satisfaction was assessed using the validated Anti-Clot Treatment Scale (ACTS), divided into the ACTS Burdens and ACTS Benefits scores; higher scores indicate greater satisfaction. Mean treatment satisfaction was compared using multivariable linear regression, adjusting for patient demographic and clinical characteristics. The effect size of the difference in means was calculated using a Cohen’s d (0.20 is considered a small effect and ≥ 0.80 is considered large). We surveyed 2217 patients, 969 taking DOACs and 1248 taking warfarin at the time of survey. Thirty-one point five percent of the cohort was aged ≥ 75 years and 43.1% were women. DOAC users were on average more satisfied with anticoagulant treatment, with higher adjusted mean ACTS Burdens (50.18 v. 48.01, p |
Databáze: | OpenAIRE |
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