MR imaging of reperfused myocardial infarction: comparison of necrosis-specific and intravascular contrast agents in a cat model
| Autor: | Hyun Woo Goo, Sung Bin Park, Tae-Hwan Lim, Joon Beom Seo, Chung Hwan Lim, Gyungyub Gong, Seung Soo Lee |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Necrosis Metalloporphyrins Myocardial Infarction Infarction Contrast Media Gadolinium Anterior Descending Coronary Artery Occlusion Carnivora Medicine Animals Radiology Nuclear Medicine and imaging cardiovascular diseases Analysis of Variance CATS biology medicine.diagnostic_test business.industry Fissipedia Magnetic resonance imaging biology.organism_classification medicine.disease Magnetic Resonance Imaging Disease Models Animal Microscopy Electron Injections Intravenous Cats Linear Models Radiology medicine.symptom business Nuclear medicine |
| Zdroj: | Radiology. 226(3) |
| ISSN: | 0033-8419 |
| Popis: | To compare T2-weighted and Gadomer-17- and bis-gadolinium mesoporphyrins-enhanced magnetic resonance (MR) images for distinguishing reversibly from irreversibly damaged myocardium in a cat model of reperfused myocardial infarction.Twelve cats underwent 90 minutes of occlusion and 90 minutes of reperfusion of the left anterior descending coronary artery. After baseline T1- and T2-weighted MR images were obtained, Gadomer-17-enhanced and bis-gadolinium mesoporphyrins-enhanced T1-weighted images were sequentially obtained for 6 hours and 2 hours, respectively. After MR imaging, all cats were sacrificed for 2,3,5-triphenyltetrazolium chloride (TTC) histochemical tissue staining. Areas of abnormal signal intensity on T2-weighted and Gadomer-17-enhanced and bis-gadolinium mesoporphyrins-enhanced T1-weighted MR images were compared with the areas of infarction seen at TTC histochemical staining by using repeated-measures two-way analysis of variance, linear regression analysis, and Bland-Altman analysis.Mean areas of abnormally high signal intensity on T2-weighted and Gadomer-17-enhanced T1-weighted MR images (43.9% of the left ventricular surface area +/- 11.9 [SD] and 37.7% +/- 10.1, respectively) were significantly larger than the mean area of myocardial infarction at TTC staining (25.7% +/- 12.5) (P.001). However, there was excellent correlation between the size of an enhancing area on bis-gadolinium mesoporphyrins-enhanced T1-weighted MR images and that of myocardial infarction at TTC staining (r = 0.916, P.001).bis-Gadolinium mesoporphyrins-enhanced T1-weighted MR images accurately reflect the area of infarction, whereas the size of infarction is overestimated on T2-weighted and Gadomer-17-enhanced T1-weighted MR images, which seem to depict the periinfarct area as well as the infarct area. |
| Databáze: | OpenAIRE |
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