Carboxylated calixarenes bind strongly to CD69 and protect CD69(+) killer cells from suicidal cell death induced by tumor cell surface ligands
| Autor: | Kateřina Hofbauerová, Alan Kadek, Petr Man, Karel Křenek, Renata Šnajdrová, Daniel Kavan, David Adámek, Pavla Bojarová, Vladimír Křen, Markéta Vančurová, Karel Bezouška, Pavel Lhoták |
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| Rok vydání: | 2009 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Programmed cell death Clinical Biochemistry Carboxylic Acids Pharmaceutical Science chemical and pharmacologic phenomena Apoptosis Ligands Biochemistry immune system diseases Cell surface receptor Antigens CD Drug Discovery Calixarene Animals Humans Lectins C-Type Receptor Molecular Biology biology Ligand Chemistry CD69 Organic Chemistry hemic and immune systems biological factors Rats Immunology biology.protein Molecular Medicine Antibody Calixarenes |
| Zdroj: | Bioorganicmedicinal chemistry. 18(4) |
| ISSN: | 1464-3391 |
| Popis: | We have recently identified a new class of high affinity ligands for CD69 leukocyte membrane receptor, carboxylated calixarenes. Of the three compounds investigated here, thiacalix[4]arene had the highest affinity for CD69 in direct binding assays, and proved to be the most specific inhibitor of CD69 identified so far in receptor precipitation and cellular activation experiments. Carboxylated calixarenes also proved effective at protection of CD69(high) lymphocytes from apoptosis triggered by a multivalent ligand or antibody. Thus, carboxylated calixarenes set a new paradigm for noncarbohydrate ligands for CD69 making them attractive for protection of killer cells in combined animal tumor therapies. |
| Databáze: | OpenAIRE |
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