The immune system endogenous anticancer mechanism
| Autor: | de Souza Ap, Cristina Bonorino |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Immunity
Cellular General Immunology and Microbiology medicine.drug_class Endogeny Dendritic cell Biology Anticancer mechanism Monoclonal antibody medicine.disease General Biochemistry Genetics and Molecular Biology Metastasis Mice Immune system Neoplasms Cancer cell medicine Cancer research Animals Humans Cytotoxic T cell Immunotherapy |
| Zdroj: | Frontiers in Bioscience. :2354-2364 |
| ISSN: | 1945-0508 1945-0494 |
| DOI: | 10.2741/e547 |
| Popis: | The genetic alterations acquired by cancer cells are identified by diverse immune mechanisms, creating a complex network of interactions that can either favor or control tumor growth. Defects and impairments in the immune system are associated with cancer development. Compelling new evidences are also available regarding the protective value of anti-tumor adaptive immune responses, both local and systemic, developed by the host. More recently, the identification of new subsets of T helper, T cytotoxic, and dendritic cells, unraveled new forms of interactions between immune and tumor cells. The immune system is a powerful ally in the control of cancer development, metastasis and recurrence, due to two important properties that are absent in most anti-cancer treatments--specificity, and long-lasting memory. These properties are being increasingly explored in cancer therapy, from the wide use of monoclonal antibodies to the still experimental dendritic cell based therapies. Now, more than ever, the preservation as well as the recruitment of immune responses in the host constitute important approaches to be applied in cancer therapy. |
| Databáze: | OpenAIRE |
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