Balancing antimicrobial activity with biological safety: bifunctional chitosan derivative for the repair of wounds with Gram-positive bacterial infections
| Autor: | Zhuang Li, Xiaoyan Ju, Shidong Jiang, Zhongwei Niu, Meng Zhu, Man Wu, Peng Liu, Ye Tian, Haigang Shi |
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| Rok vydání: | 2020 |
| Předmět: |
Biomedical Engineering
02 engineering and technology Bacterial growth 010402 general chemistry 01 natural sciences Microbiology Chitosan chemistry.chemical_compound medicine General Materials Science Bifunctional Cytotoxicity integumentary system biology Chemistry General Chemistry General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Antimicrobial medicine.disease Hemolysis 0104 chemical sciences 0210 nano-technology Wound healing Bacteria |
| Zdroj: | Journal of materials chemistry. B. 6(23) |
| ISSN: | 2050-7518 |
| Popis: | Infection control and the promotion of healing are two key factors during the wound repair process. However, it is still a major challenge for one material to inhibit bacterial growth efficiently and promote wound healing at the same time. Here, a bifunctional chitosan derivative (CS-G/mPEG) was prepared by the successive modification of chitosan with carboxymethoxypolyethylene glycol (mPEG-COOH) and aminoiminomethanesulfonic acid (AIMSOA). We demonstrated that CS-G/mPEG can selectively disrupt bacterial membranes with high efficiency and thus kill Gram-positive bacteria without inducing hemolysis or cytotoxicity. In rats with full-thickness skin wounds infected with Staphylococcus aureus bacteria, CS-G/mPEG inhibited the growth of the bacteria and accelerated the healing of the wounds. Owing to the balance between the antimicrobial activity and biological safety of CS-G/mPEG, this bifunctional chitosan derivative is promising as an ideal anti-infective wound-repairing material for managing wounds with Gram-positive bacterial infections. |
| Databáze: | OpenAIRE |
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