Mitogenic inhibition and effect on survival of mice bearing L1210 leukemia using a combination of dehydroascorbic acid and hydroxycobalamin
| Autor: | Hart T, Poydock Me, Takita H, Kelly D, Harguindey S |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Cancer Research
medicine.medical_specialty Ratón Drug Evaluation Preclinical chemistry.chemical_compound Mice Internal medicine Hydroxocobalamin Antineoplastic Combined Chemotherapy Protocols medicine Animals Vitamin B12 Leukemia L1210 Mitosis Cells Cultured business.industry Ascorbic acid Dehydroascorbic Acid In vitro Endocrinology Oncology chemistry Mice Inbred DBA L1210 cells Dehydroascorbic acid Female business Cell Division medicine.drug |
| Zdroj: | American journal of clinical oncology. 8(3) |
| ISSN: | 0277-3732 |
| Popis: | The present study was designed to test the effect of a combination of dehydroascorbic acid (DHA) and hydroxycobalamin (vitamin B12) on the survival of mice bearing L1210 leukemia. Results showed a significant increase in survival of treated mice compared with controls (p less than or equal to 0.0001) (Student's t-test). This positive effect was significantly lost when DHA was substituted by ascorbic acid (AA) in the same experimental conditions. In vitro findings also revealed that the DHA-B12 combination specifically inhibited mitoses of L1210 cells while non-neoplastic L929 cells were not affected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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