A highly immunogenic vaccine against A/H7N9 influenza virus

Autor:	Amelia R. Hofstetter, Suryaprakash Sambhara, Ian A. York, Jin Hyang Kim, Adrian J. Reber, Ahmed O. Hassan, Shivaprakash Gangappa, Justine S. Liepkalns, Jacqueline M. Katz, Suresh K. Mittal, Ram P. Kamal, Weiping Cao, Samuel Amoah, James Stevens
Rok vydání:	2016
Předmět:	0301 basic medicine Protective immunity Influenza vaccine Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus Antibodies Viral Influenza A Virus H7N9 Subtype medicine.disease_cause Article Virus Adenoviridae Mice 03 medical and health sciences Orthomyxoviridae Infections Neutralization Tests Immunity Pandemic medicine Animals Duck embryo vaccine Immunity Cellular Mice Inbred BALB C General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Virology Immunity Humoral 030104 developmental biology Infectious Diseases Influenza Vaccines Immunology biology.protein Molecular Medicine business
Zdroj:	Vaccine. 34:744-749
ISSN:	0264-410X
DOI:	10.1016/j.vaccine.2015.12.062
Popis:	Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/(H7N9) viral challenge suggesting its potential utility as a pandemic vaccine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3c610ac3984305ef35edfc66dc4709 https://doi.org/10.1016/j.vaccine.2015.12.062 Zobrazit plný text záznamu Full Text from ScienceDirect