Antiproliferative activity of retinoids, interferon α and their combination in five human transformed cell lines
| Autor: | W. Bollag, R. Peck, J.R. Frey |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Acute promyelocytic leukemia
Cancer Research medicine.medical_specialty medicine.medical_treatment Cell Alpha interferon Tretinoin In Vitro Techniques Biology Retinoids Internal medicine Tumor Cells Cultured medicine Humans Isotretinoin skin and connective tissue diseases Interferon alfa Cell growth Drug Synergism medicine.disease Acitretin Growth Inhibitors medicine.anatomical_structure Cytokine Endocrinology Oncology Cell culture Interferon Type I Cancer research Cell Division medicine.drug |
| Zdroj: | Cancer Letters. 57:223-227 |
| ISSN: | 0304-3835 |
| Popis: | Tretinoin, isotretinoin and acitretin were examined for their capacity to modulate the proliferation of the cell lines: HL-60 (acute promyelocytic leukemia), MCF7 (mammary carcinoma), SCC4, SCC15 and A431 (squamous cell carcinomas). Retinoids inhibited proliferation to a varying extent in all 5 cell lines. The cytokine IFN alpha had a significant antiproliferative effect only on HL-60, SCC4 and SCC15. The combination of retinoids with IFN alpha led in all 5 cell lines to a more profound reduction in proliferation than either retinoids or IFN alpha alone. |
| Databáze: | OpenAIRE |
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