Cell death in protists without mitochondria
| Autor: | Catherine Brenner, Claude-Olivier Sarde, Olivier Chose, Delphine Gerbod, Alberto Roseto, Christophe Noël, Monique Capron, Juan-Carlos Jimenez, Eric Viscogliosi |
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| Přispěvatelé: | Génie Enzymatique et Cellulaire (GEC), Université de Technologie de Compiègne (UTC)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Programmed cell death
Hydrogenosome Apoptosis Biology Mitochondrion medicine.disease_cause Genome General Biochemistry Genetics and Molecular Biology 03 medical and health sciences History and Philosophy of Science Organelle parasitic diseases medicine Trichomonas vaginalis Giardia lamblia Animals Humans Symbiosis 030304 developmental biology 0303 health sciences Cell Death 030306 microbiology General Neuroscience Protist Eukaryota 3. Good health Cell biology Mitochondria Hydrogen |
| Zdroj: | Annals of the New York Academy of Sciences Annals of the New York Academy of Sciences, Wiley, 2003, 1010, pp.559-564 |
| ISSN: | 0077-8923 1749-6632 |
| Popis: | Some protozoans, such as Trichomonad species, do not possess mitochondria. Most of the time, they harbor another type of membrane-bounded organelle, called hydrogenosome from its capacity to produce H2. This is the case for the human parasite Trichomonas vaginalis. Some other parasites, such as the protist Giardia lamblia, do not harbor any of these organelles. From this observation arises naturally a naive question: How do cells die when the mitochondrion, the cornerstone of apoptotic process, is absent? Data strongly suggest that the mitochondrion and the hydrogenosome arose from a common ancestral endosymbiont. But hydrogenosomes do not appear to directly substitute for mitochondria in apoptotic functions. Thus, it appears judicious to examine more closely the genome of unicellular cells, which do not harbor mitochondria, and search for new molecules that could participate in the apoptotic process in these microorganisms. |
| Databáze: | OpenAIRE |
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