Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

Autor: João Antonio Pêgas Henriques, Priscila dos Santos Silveira, José Eduardo Vargas, Renato David Puga, Iuri Marques de Oliveira, Temenouga N. Guecheva, Cristiano Trindade, André Luiz Mendes Juchem, Cláudia Pessoa
Rok vydání: 2019
Předmět:
Zdroj: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Volume 2019
Repositorio Digital USB
Universidad Simón Bolívar
instacron:Universidad Simón Bolívar
ISSN: 1942-0994
1942-0900
Popis: Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.
Databáze: OpenAIRE
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