Acoustic startle response in rats predicts inter-individual variation in fear extinction
Autor: | Ryan G. Parsons, Amanda S Russo |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Reflex Startle medicine.medical_specialty Startle response Fear memory genetic structures Cognitive Neuroscience Conditioning Classical Population Individuality Experimental and Cognitive Psychology Audiology behavioral disciplines and activities Fear-potentiated startle Extinction Psychological Developmental psychology Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine Animals Fear conditioning Freezing Reaction Cataleptic education education.field_of_study medicine.diagnostic_test Fear Extinction (psychology) Rats Freezing behavior 030104 developmental biology Acoustic Stimulation Conditioning Psychology Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Neurobiology of Learning and Memory. 139:157-164 |
ISSN: | 1074-7427 |
Popis: | Although a large portion of the population is exposed to a traumatic event at some point, only a small percentage of the population develops post-traumatic stress disorder (PTSD), suggesting the presence of predisposing factors. Abnormal acoustic startle response (ASR) has been shown to be associated with PTSD, implicating it as a potential predictor of the development of PTSD-like behavior. Since poor extinction and retention of extinction learning are characteristic of PTSD patients, it is of interest to determine if abnormal ASR is predictive of development of such deficits. To determine whether baseline ASR has utility in predicting the development of PTSD-like behavior, the relationship between baseline ASR and freezing behavior following Pavlovian fear conditioning was examined in a group of adult, male Sprague-Dawley rats. Baseline acoustic startle response (ASR) was assessed preceding exposure to a Pavlovian fear conditioning paradigm where freezing behavior was measured during fear conditioning, extinction training, and extinction testing. Although there was no relationship between baseline ASR and fear memory following conditioning, rats with low baseline ASR had significantly lower magnitude of retention of the extinction memory than rats with high baseline ASR. The results suggest that baseline ASR has value as a predictive index of the development of a PTSD-like phenotype. |
Databáze: | OpenAIRE |
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