Postoperative volumetric modulated arc therapy for sinonasal cancer: Improved survival compared with 3D conformal radiation therapy
| Autor: | Frederic-Moreau, Thomas, Piram, Lucie, Bellini, Romain, Martin, Fanny, Miroir, Jessica, Saroul, Nicolas, Pham Dang, Nathalie, Lapeyre, Michel, Biau, Julian, Frederic‐moreau, Thomas |
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| Přispěvatelé: | Université libre de Bruxelles (ULB), service de radiothérapie, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER-UNICANCER, ORL chirurgie Cervico-Faciale, CHU Clermont-Ferrand, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Alexis Vautrin (CAV), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), UNICANCER |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Simultaneous integrated boost medicine.medical_treatment education Improved survival VMAT [SDV.CAN]Life Sciences [q-bio]/Cancer Adenocarcinoma radiation therapy 3D CONFORMAL RADIATION THERAPY 030218 nuclear medicine & medical imaging Cohort Studies 03 medical and health sciences 0302 clinical medicine Humans postoperative Medicine Stage (cooking) Aged Aged 80 and over business.industry Sinonasal cancer Middle Aged Volumetric modulated arc therapy 3. Good health Survival Rate Radiation therapy Treatment Outcome Otorhinolaryngology sinonasal cancer 030220 oncology & carcinogenesis Toxicity Carcinoma Squamous Cell outcome Female Radiotherapy Adjuvant Radiotherapy Intensity-Modulated Nuclear medicine business Paranasal Sinus Neoplasms |
| Zdroj: | Head & Neck Head & Neck, Wiley, 2018, 41 (2), pp.448-455. ⟨10.1002/hed.25410⟩ Head and Neck Head and Neck, Wiley, 2018, 41 (2), pp.448-455. ⟨10.1002/hed.25410⟩ |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | BACKGROUND Prospective evaluation of the results of volumetric modulated arc therapy (VMAT) for sinonasal cancer compared to 3D conformal radiation therapy (3DCRT). MATERIALS AND METHODS We prospectively evaluated 34 patients (pts) treated with postoperative VMAT with simultaneous integrated boost (SIB; RapidArc) from 2011 to 2015. These pts were retrospectively compared with 24 pts treated with 3DCRT from 2003 to 2011. The two sets were not significantly different on sex, mean age, tumor site, stage, histology. Efficacy and toxicity were evaluated. RESULTS Median follow-up was 45 months (range: 6-143 months). Three-year overall survival was 85.2% in VMAT-SIB versus 65.2% in 3DCRT (P = .02). Three-year local control was 81.2% in VMAT-SIB versus 62.5% in 3DCRT (P = .04). There was a reduction of acute ( |
| Databáze: | OpenAIRE |
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