| Autor: |
Shubing Tang, Min Li, Lixiang Chen, Aguang Dai, Zhi Liu, Mangteng Wu, Jingyi Yang, Hongyun Hao, Jingdan Liang, Xiaohui Zhou, Zhikang Qian |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
ACS Applied Bio Materials. 5:3329-3337 |
| ISSN: |
2576-6422 |
| DOI: |
10.1021/acsabm.2c00328 |
| Popis: |
Thousands of breakthrough infections are confirmed after intramuscular (i.m.) injection of the approved vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two major factors might contribute to breakthrough infections. One is the emergence of mutant variants of SARS-CoV-2, and the other is that i.m. injection has an inefficient ability to activate mucosal immunity in the upper respiratory tract. Here, we devised a dual-chambered nanocarrier that can codeliver the adjuvant CBLB502 with prefusion-spike (pre-S) onto a ferritin nanoparticle. This vaccine enabled enhanced systemic and local mucosal immunity in the upper and lower respiratory tract. Further, codelivery of CBLB502 with pre-S induced a Th1/Th2-balanced immunoglobulin G response. Moreover, the codelivery nanoparticle showed a Th1-biased cellular immune response as the release of splenic INF-γ was significantly heightened while the level of IL-4 was elevated to a moderate extent. In general, the developed dual-chambered nanoparticle can trigger multifaceted immune responses and shows great potential for mucosal vaccine development. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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