Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure
| Autor: | Oliver Pabst, Andreas Krueger, Milas Ugur, Manoj B. Menon, Olga Schulz |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
CD4-Positive T-Lymphocytes
Pathology medicine.medical_specialty Population General Physics and Astronomy Biology Real-Time Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Mice Peyer's Patches Antigen Cell Movement Follicular phase medicine Lymph node stromal cell Animals Humans Antigens education Lymph node DNA Primers education.field_of_study Multidisciplinary Histological Techniques General Chemistry Flow Cytometry Mice Inbred C57BL Lymphatic system medicine.anatomical_structure Cell Tracking Immunology T cell migration Lymph Lymph Nodes |
| Zdroj: | Nature communications. 5 |
| ISSN: | 2041-1723 |
| Popis: | Effector and memory CD4(+) T cells acquire distinct migratory properties depending on the type and location of the immune responses. Due to the highly dynamic nature of T cell circulation, the comprehensive analysis of these migratory routes requires dedicated experimental approaches. Here, we analyse the migration of effector/memory CD4(+) T cells by long-term in vivo cell tracking. We identify a resident population of antigen-experienced CD4(+) T cells that resides in lymph nodes and Peyer's patches without circulation or proliferation. Resident CD4(+) T cells constitute up to 50% of all effector/memory cells, including, but not limited to, follicular helper T cells. Furthermore, these non-circulating T cells possess a distinct T cell receptor repertoire and accumulate in Peyer's patches after continuous oral antigen exposure. Our results provide the first direct evidence for a resident population of effector/memory CD4(+) T cells that is retained in lymphoid tissues. |
| Databáze: | OpenAIRE |
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