Acute lymphoblastic leukemia with 4;11 translocation analyzed by a multi-modal strategy of conventional cytogenetics, FISH, morphology, flow cytometry and molecular genetics, and review of the literature
| Autor: | Hon Fong L. Mark, Jila Khorsand, Fernando Chaves, Eric P. Winer, Tara Williams, Cynthia Hayne |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Pathology Clinical Biochemistry Chromosomal translocation Computational biology Biology Translocation Genetic Pathology and Forensic Medicine Molecular cytogenetics Cytogenetics Bone Marrow Acute lymphocytic leukemia Molecular genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Acute leukemia medicine.diagnostic_test Chromosomes Human Pair 11 Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Flow Cytometry medicine.disease medicine.anatomical_structure Female Bone marrow Chromosomes Human Pair 4 Fluorescence in situ hybridization |
| Zdroj: | Experimental and Molecular Pathology. 81:62-71 |
| ISSN: | 0014-4800 |
| Popis: | We report a case of acute lymphoblastic leukemia (ALL) with a 4;11 translocation. Metaphase cells and interphase nuclei derived from a routine unstimulated culture of bone marrow were analyzed using a combined strategy of G-banding and fluorescent in situ hybridization (FISH) in addition to hematopathological analysis, flow cytometry, and molecular genetics. This multimodal approach enables a successful correlation of pathology and cytogenetics to support a comprehensive diagnosis of the patient. Meaningful prognostication and appropriate therapeutic considerations are possible only when accurate diagnostic information is given. We further search and review the literature for the most up-to-date information currently available for this subtype of ALL in the constantly evolving field of molecular cytogenetics. |
| Databáze: | OpenAIRE |
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