Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters
| Autor: | Ronald F. Schell, J L Schmitz, Steven D. Lovrich, J E Coe, Steven M. Callister |
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| Rok vydání: | 1991 |
| Předmět: |
Blotting
Western Immunology Enzyme-Linked Immunosorbent Assay Spirochaetaceae Microbiology Immunoglobulin G Lyme disease Borrelia burgdorferi Group Cricetinae Blocking antibody medicine Animals Borrelia burgdorferi Lyme Disease biology bacterial infections and mycoses medicine.disease biology.organism_classification Antibodies Bacterial Virology Disease Models Animal Titer Infectious Diseases Immunoglobulin M biology.protein Electrophoresis Polyacrylamide Gel Parasitology Antibody Research Article |
| Zdroj: | Infection and Immunity. 59:1916-1921 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | We show that serum obtained from normal hamsters infected with Borrelia burgdorferi can confer complete protection on irradiated recipients challenged with the Lyme spirochete. Borreliacidal activity was detected 7 days after infection, peaked at weeks 3 to 5, and thereafter decreased. Relatively high borreliacidal activity was detected in immune serum at weeks 3 and 5 of infection. The borreliacidal activity did not correlate with antibody used for the serodiagnosis of Lyme disease, which remained elevated throughout experimental infection. Our results also demonstrated that blocking antibody and antigenic variation in B. burgdorferi did not account for the decreasing titer of protective antibody. These findings indicate that protection against reinfection gradually wanes. |
| Databáze: | OpenAIRE |
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