Some actions of sympathomimetic amines and their antagonists on mouse superfused ileum
| Autor: | B. J. Large, Jacqueline L. Wright |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine medicine.medical_treatment Short Communications Ileum Propranolol In Vitro Techniques Norepinephrine (medication) Hydroxydopamines Mice Norepinephrine Phenylephrine Phentolamine Internal medicine Isoprenaline Animals Medicine Nerve Growth Factors Sympathomimetics Pharmacology Dose-Response Relationship Drug business.industry Immune Sera Isoproterenol Perfusion Endocrinology medicine.anatomical_structure Sympathectomy Sympatholytics Female business medicine.drug |
| Zdroj: | British Journal of Pharmacology. 49:702-705 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1973.tb08548.x |
| Popis: | Superfused segments of mouse ileum exhibited spontaneous movement which Mwere inhibited by sympathomimetic amines. Isoprenaline and adrenaline were approximately equipotent and about 15 times more potent than either noradrenaline or phenylephrine. Supersensitivity developed to all these agents when mice had been 'sympathectomized' with NGF-antiserum or 6-hydroxydopamine and it was more pronounced with the latter treatment. Responses to the amines were reduced by phentolamine and propranolol, alone or in combination, with the exception of phenylephrine, the responses to which were simply shortened in duration after,β-adrenoceptor blockade. No qualitative changes were evident in the effects of the blocking agents after 'sympathectomy'. |
| Databáze: | OpenAIRE |
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