Helicobacter pyloritargets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma
| Autor: | Mathias Oertli, Anne Müller |
|---|---|
| Přispěvatelé: | University of Zurich, Oertli, Mathias |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Allergy Inflammasomes Biology T-Lymphocytes Regulatory Microbiology 2726 Microbiology (medical) Immune tolerance 03 medical and health sciences 0302 clinical medicine Immune system Immunity Immunopathology Hypersensitivity Immune Tolerance medicine Animals Humans 2715 Gastroenterology Immune Evasion 030304 developmental biology 0303 health sciences Helicobacter pylori 10061 Institute of Molecular Cancer Research 2404 Microbiology Interleukin-18 Gastroenterology Forkhead Transcription Factors Inflammasome Dendritic Cells 2725 Infectious Diseases Inflammatory Bowel Diseases medicine.disease biology.organism_classification Asthma Article Addendum 3. Good health Disease Models Animal Chronic infection Infectious Diseases Immunology 570 Life sciences biology 030215 immunology medicine.drug |
| Zdroj: | Gut microbes Gut Microbes |
| ISSN: | 1949-0984 1949-0976 |
| DOI: | 10.4161/gmic.21750 |
| Popis: | The bacterial pathogen Helicobacter pylori is predominantly known for its tight association with peptic ulcer disease and gastric cancer. However recent evidence suggests that chronic infection with H. pylori may also be beneficial to the host by conferring protection against allergies asthma and inflammatory bowel diseases. The protective effects of H. pylori depend on highly suppressive regulatory T cells. In this addendum we summarize results showing that H. pylori infection efficiently re programs dendritic cells (DCs) toward a tolerance promoting phenotype; their "tolerogenic" activity requires inflammasome activation and the secretion of interleukin 18. H. pylori experienced DCs fail to induce T cell effector functions but efficiently induce FoxP3 expression in naive T cells in vitro and in vivo. The experimental depletion of DCs breaks tolerance and results in improved infection control but also in aggravated T cell driven immunopathology. In summary we propose that H. pylori evades adaptive immune responses by re programming DCs in favor of tolerance over immunity. © 2012 Landes Bioscience. |
| Databáze: | OpenAIRE |
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