Oxidative Stress in Renal Anemia of Hemodialysis Patients Is Mitigated by Epoetin Treatment
| Autor: | Francesco Carluccio, Werner Siems, Tilman Grune, H. Hampl, Sonja Radenkovic |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Anemia medicine.medical_treatment Enzyme-Linked Immunosorbent Assay medicine.disease_cause Gastroenterology Lipid peroxidation Hemoglobins chemistry.chemical_compound Renal Dialysis Renal anemia Malondialdehyde Internal medicine medicine Humans Chronic hemodialysis Erythropoietin Chromatography High Pressure Liquid Aged Aldehydes Blood Proteins General Medicine Middle Aged medicine.disease Recombinant Proteins Epoetin Alfa Oxidative Stress Endocrinology chemistry Nephrology Hematinics Kidney Failure Chronic Female Hemodialysis Cardiology and Cardiovascular Medicine Oxidative stress medicine.drug |
| Zdroj: | Kidney and Blood Pressure Research. 28:295-301 |
| ISSN: | 1423-0143 1420-4096 |
| DOI: | 10.1159/000090184 |
| Popis: | Background/Aims: Oxidative stress often occurs in chronic hemodialysis (HD) patients. The objective of our study was to investigate the interrelationship between oxidative stress and the degree of renal anemia. Methods: In 107 consecutive HD patients, serum concentrations of two major aldehydic lipid peroxidation (LPO) products, 4-hydroxynonenal (HNE) and malondialdehyde (MDA), and of protein carbonyls were analyzed as parameters of oxidative stress and related to the degree of renal anemia. Additionally, in 76 patients treated with epoetin long-term changes in the serum levels of aldehydic LPO products were observed. Results: In HD patients, serum levels of HNE, MDA, and protein carbonyls are increased in comparison to controls. The lower the hemoglobin, i.e. the stronger the degree of renal anemia, the higher the serum concentrations of HNE, MDA, and protein carbonyls. The HNE and MDA levels decreased during HD. Long-term studies on the correction of renal anemia by epoetin demonstrated a mitigation of oxidative stress during this therapy. During periods of 1 and 2 years, it was observed that the serum levels of HNE and MDA could be reduced. Conclusion: Chronic renal failure is connected with oxidative stress which correlates with the degree of renal anemia, and the serum levels of aldehydic LPO products could be reduced during correction of renal anemia by epoetin. |
| Databáze: | OpenAIRE |
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