Regulative influence ofo-aminobenzoic acid (OABA) on the biosynthesis of nourseothricin in cultures ofStreptomyces noursei JA 3890b. V. Effect of OABA on cytochrome levels and amino acid transport
| Autor: | H. Bocker, Udo Gräfe, Heinz Thrum, A. Steudel |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Cytochrome
Catabolite repression Models Biological Applied Microbiology and Biotechnology Electron Transport chemistry.chemical_compound Genetics Aminobenzoic acid ortho-Aminobenzoates Amino Acids Secondary metabolism chemistry.chemical_classification biology Catabolism Biological Transport General Medicine biology.organism_classification Streptomyces Anti-Bacterial Agents Amino acid Streptomyces noursei chemistry Biochemistry Streptothricins biology.protein Cytochromes Nourseothricin Oxidation-Reduction |
| Zdroj: | Zeitschrift für allgemeine Mikrobiologie. 20:185-194 |
| ISSN: | 1521-4028 0044-2208 |
| Popis: | o-Aminobenzoic acid (OABA) known by its stimulatory effect on streptothricin biosynthesis by Streptomyces noursei JA 3890b was found to suppress specifically the formation of cytochrome a-type terminal oxidase while the levels of the b- and c-type cytochromes apparently remained unaffected. This change was coupled to decreased capacity of transport of u-14C-L-alanine and u-14C-L-glutamic acid into the mycelium, giving rise to delay of amino acid catabolism and decreased production of nitrogen catabolites within the cell. The above results provide supporting evidence for conjectures recently published by us concerning the control by nitrogen catabolites of the secondary metabolism of this strain. As a summary a scheme is proposed showing several hypothetic mechanisms by which nitrogen catabolite regulation of nourseothricin production could be accomplished. |
| Databáze: | OpenAIRE |
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