Coinfection of Epstein-Barr virus, cytomegalovirus, herpes simplex virus, human papillomavirus and anal intraepithelial neoplasia in HIV patients in Amazon, Brazil
| Autor: | José Ribamar de Araújo, Carolina Marinho da Costa, Aline Lury Hada, Rosilene Viana de Andrade, Adriana Gonçalves Daumas Pinheiro Guimarães, Luiz Carlos de Lima Ferreira, Renata Silva Galvao |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Sexually transmitted disease
anal cancer neoplasia intraepitelial anal Congenital cytomegalovirus infection RC799-869 Virus anal intraepithelial neoplasia Acquired immunodeficiency syndrome (AIDS) medicine Epstein-Barr vírus Anal cancer Epstein-Barr virus human papillomavirus cytomegalovirus business.industry Gastroenterology coinfecção anal virus diseases papilomavírus humano citomegalovírus câncer anal sexually transmitted disease anal coinfection Diseases of the digestive system. Gastroenterology Anal canal medicine.disease herpes simplex virus doenças sexualmente transmissíveis Virology medicine.anatomical_structure Immunology Coinfection herpes simples vírus business Viral load |
| Zdroj: | Journal of Coloproctology (Rio de Janeiro) v.32 n.1 2012 Journal of Coloproctology (Rio de Janeiro. Online) Sociedade Brasileira de Coloproctologia (SBCP) instacron:SBCP Journal of Coloproctology, Vol 32, Iss 1, Pp 18-25 (2012) Journal of Coloproctology (Rio de Janeiro), Volume: 32, Issue: 1, Pages: 18-25, Published: MAR 2012 |
| Popis: | OBJECTIVE: The prevention of anal cancer is a goal of worldwide Aids support centers. Despite the efforts that have been made and progress in the antiretroviral therapy, effective disease control remains elusive. Difficulty in preventing anal cancer may result from the ineffectiveness of highly active antiretroviral therapy on the human papillomavirus (HPV) since the coinfection with HIV and HPV appears to increase the risk of HPV-infected cells, becoming cancerous. METHODS: We evaluated 69 HIV-positive and 30 HIV-negative male patients who underwent cytological evaluation by RT-PCR for the presence of HPV, Epstein-Barr virus, cytomegalovirus and herpes virus types (HSV) 1 and 2, and histopathology analysis of the anal canal. RESULTS: The prevalence of anal intraepithelial neoplasia was 35% and it was restricted to HIV-positive patients. Patients infected with high-risk HPV and with fewer than 50 TCD4 cells/µL showed an anal intraepithelial neoplasia rate of 85.7% compared to those with TCD4 cells >200 cells/µL (pOBJETIVO: A prevenção do câncer anal tem sido aplicada pelos centros de apoio a pacientes com Aids em todo o mundo. Apesar dos esforços empregados, o eficaz controle da doença permanece distante. A dificuldade na prevenção do câncer anal pode resultar, em parte, da ineficácia da ação da terapia antirretroviral sobre o papilomavírus humano (HPV), pois a coinfecção com HIV e HPV parece aumentar o risco das células infectadas pelo HPV em tornarem-se cancerosas. MÉTODOS: Foram avaliados 69 HIV-positivos e 30 pacientes HIV-negativos do sexo masculino, que foram submetidos à avaliação citológica anal por real time-PCR para a presença de HPV, vírus Epstein-Barr, citomegalovírus e herpes vírus tipos (HSV) 1 e 2 além da análise histopatológica de fragmento de mucosa do canal anal. RESULTADOS: A prevalência de neoplasia intraepitelial anal foi de 35% e foi restrita a pacientes HIV-positivos. Os pacientes infectados com o HPV de alto risco e com contagem inferior a 50 células TCD4/µL mostraram taxa de neoplasia intraepitelial anal de 85,7%. A diferença foi significativa quando comparado a pacientes com células TCD4 >200 células/µL (p |
| Databáze: | OpenAIRE |
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