Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains

Autor:	Patrice Francois, Yan Q. Xiong, Jacques Schrenzel, Arnold S. Bayer, Soo-Jin Yang, Andreas Peschel, Paul M. Dunman
Rok vydání:	2009
Předmět:	Staphylococcus aureus Micrococcaceae Daptomycin/ pharmacology medicine.drug_class Anti-Bacterial Agents/ pharmacology Staphylococcus aureus/ drug effects/genetics Antibiotics Mutant Virulence Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology chemistry.chemical_compound Bacterial Proteins Daptomycin Mechanisms of Resistance Bacterial Proteins/ genetics/physiology Drug Resistance Bacterial medicine Humans Pharmacology (medical) Aminoacyltransferases/ genetics/physiology Antibacterial agent Pharmacology ddc:616 Lipopeptide biology.organism_classification Aminoacyltransferases Anti-Bacterial Agents Infectious Diseases chemistry Mutation medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy, Vol. 53, No 6 (2009) pp. 2636-2637
ISSN:	1098-6596 0066-4804
Popis:	We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF -mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e296052a1bea212bf77b5188383e5ee https://pubmed.ncbi.nlm.nih.gov/19289517 Zobrazit plný text záznamu