Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

Autor: Silvia J Hernández-Martínez, Lydia G. Rivera-Morales, Ana Carolina Martínez-Torres, Edmundo Erbey Castelán-Maldonado, Gerardo del Carmen Palacios-Saucedo, Angel Zavala-Pompa, Vianey Gonzalez-Villasana, Rocio Ortiz-Lopez, Julio C. Serna-Hernández, Cristina Rodríguez-Padilla, Maribel Montufar-Martinez, Ricardo García-Cabello, Saira Berenice Burciaga-Bernal, Monica Valeria Alonzo-Morado, Jose Manuel Vazquez-Guillen, Martha S. Montalvo-Bañuelos, Ethel C. Sánchez-Fresno
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Larynx
Pathology
medicine.medical_specialty
Human papillomavirus
Merkel cell polyomavirus
lcsh:Medicine
medicine.disease_cause
General Biochemistry
Genetics and Molecular Biology
Virus
03 medical and health sciences
0302 clinical medicine
Laryngeal cancer
Virology
Squamous cell carcinoma
Genotype
medicine
Epstein-Barr virus
Respiratory Medicine
biology
business.industry
Merkel cell Polyomavirus
General Neuroscience
lcsh:R
virus diseases
General Medicine
biology.organism_classification
medicine.disease
Epstein–Barr virus
female genital diseases and pregnancy complications
030104 developmental biology
medicine.anatomical_structure
Oncology
Otorhinolaryngology
030220 oncology & carcinogenesis
Coinfection
Etiology
General Agricultural and Biological Sciences
Carcinogenesis
business
Zdroj: PeerJ
PeerJ, Vol 6, p e5834 (2018)
ISSN: 2167-8359
Popis: Background Human papillomavirus (HPV) is recognized as an important risk factor for laryngeal carcinogenesis. Although HPV-16 and 18 have been strongly implicated, the presence of other high-risk HPV (HR-HPV) genotypes or the coinfection with Epstein-Barr virus (EBV) or Merkel cell polyomavirus (MCPV) may increase the risk, but their etiological association has not been definitively established. Methods We characterized the genotype-specific HPV and the frequency of EBV and MCPV infections through the detection of their DNA in 195 laryngeal specimens of squamous cell carcinoma (SCC) histologically confirmed. Results HPV DNA was detected in 93 (47.7%) specimens. HPV-11 was the most frequent with 68 cases (73.1%), and HPV-52 was the most frequently HR-HPV found with 51 cases, which corresponds to 54.8% of all HPV-positive specimens. EBV DNA was detected in 54 (27.7%) tumor tissue specimens of which 25 (46.3%) were in coinfection with HPV. MCPV DNA was detected only in 11 (5.6%) cases of which 5 (45.4%) were in coinfection with an HR-HPV. No association between the presence of DNA of the three examined viruses and the patient smoking habits, alcohol consumption, age, the keratinization status, differentiation grade, or localization of the tumor in the larynx were found. Discussion HPV-52 was the most prevalent HR-HPV, which may suggest that this and other genotypes in addition to HPV-16 and 18 could be considered for prophylaxis. However, further studies including non-cancer larynx cases and the evaluation of other molecular markers and viral co-infection mechanisms are needed to determine the role of the different HR-HPV genotypes, EBV, and MCPV in the etiology of SCC of the larynx.
Databáze: OpenAIRE
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