Enhanced insulin secretion and calcium uptake by Zucker 'fatty' rat islets
| Autor: | Tolman El, Pansini Ar |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Calcium In Vitro Techniques Biochemistry Rats Mutant Strains Islets of Langerhans Endocrinology Internal medicine Insulin Secretion Extracellular medicine Animals Insulin Insulin secretion geography geography.geographical_feature_category Dose-Response Relationship Drug Chemistry Pancreatic islets Biochemistry (medical) nutritional and metabolic diseases General Medicine Islet Calcium uptake Insulin oscillation Rats Rats Zucker medicine.anatomical_structure Glucose |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 13(8) |
| ISSN: | 0018-5043 |
| Popis: | The relationship of the net uptake of calcium to insulin secretion by pancreatic islets isolated from Zucker "fatty" rats and their lean counterparts was studied. Islets from "fatty" rats secreted 1.5 to 3 times as much insulin as did the lean rat islets over a glucose concentration range of 0 to 27.7 mM. Over the same glucose concentration range, calcium accumulation was 2-fold greater in islets from the "fatty" rats than from the others. Both insulin secretion and calcium uptake were 2 to 3 fold greater for islets from the "fatty" rats than those from the lean animals over an extracellular calcium concentration range of up to 5 mEq/L. The data indicate that for islets isolated from Zucker "fatty" rats insulin hypersecretion in response to glucose and extra-cellular calcium is associated with enhanced calcium accumulation. |
| Databáze: | OpenAIRE |
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