Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study

Autor: Taulant Muka, Adela Brahimaj, Oscar H. Franco, Joop S.E. Laven, Abbas Dehghan, Maryam Kavousi
Přispěvatelé: Epidemiology, Obstetrics & Gynecology
Rok vydání: 2016
Předmět:
Male
Endocrinology
Diabetes and Metabolism
DHEA sulphate
Type 2 diabetes
Cohort Studies
Rotterdam Study
0302 clinical medicine
Risk Factors
Sex Hormone-Binding Globulin
1114 Paediatrics And Reproductive Medicine
polycyclic compounds
Medicine
Testosterone
030212 general & internal medicine
DHEA
skin and connective tissue diseases
INSULIN SENSITIVITY
Dehydroepiandrosterone Sulfate
POLYCYSTIC-OVARY-SYNDROME
Middle Aged
POSTMENOPAUSAL WOMEN
1117 Public Health And Health Services
Female
Life Sciences & Biomedicine
hormones
hormone substitutes
and hormone antagonists
endocrine system
medicine.medical_specialty
SEX-DIFFERENCES
DHEAS
Food supplement
ELDERLY-MEN
Dehydroepiandrosterone
030209 endocrinology & metabolism
Carbohydrate metabolism
Lower risk
Article
Endocrinology & Metabolism
03 medical and health sciences
SDG 3 - Good Health and Well-being
Internal medicine
Internal Medicine
Humans
Androstenedione
ADVANCING AGE
Aged
Science & Technology
business.industry
GLUCOSE-UPTAKE
DEHYDROISOANDROSTERONE SULFATE
1103 Clinical Sciences
Human physiology
medicine.disease
Endocrinology
Diabetes Mellitus
Type 2
SULFATE CONCENTRATIONS
Independent marker
business
human activities
Zdroj: Diabetologia
Diabetologia, 60(1), 98-106. Springer-Verlag
ISSN: 1432-0428
0012-186X
Popis: Aims/hypothesis Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. Methods We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study. Type 2 diabetes was defined as a fasting blood glucose ≥7.0 mmol/l or a non-fasting blood glucose ≥11.1 mmol/l. Results During a median follow-up of 10.9 years, 643 patients with incident type 2 diabetes were identified. After adjusting for age, sex, cohort, fasting status, fasting glucose and insulin, and BMI, both serum DHEA levels (per 1 unit natural log-transformed, HR 0.76, 95% CI 0.67, 0.87) and serum DHEAS levels (per 1 unit natural log-transformed, HR 0.82, 95% CI 0.73, 0.92) were inversely associated with risk of type 2 diabetes in the total population. Further adjustment for alcohol, smoking, physical activity, prevalent cardiovascular disease, serum total cholesterol, use of lipid-lowering medications, systolic BP, treatment for hypertension, C-reactive protein, oestradiol and testosterone did not substantially affect the association between DHEA and incident type 2 diabetes (per 1 unit natural log-transformed, HR 0.80, 95% CI 0.65, 0.99), but abolished the association between DHEAS and type 2 diabetes. Androstenedione was not associated with risk of type 2 diabetes, nor was DHEAS to DHEA ratio. Conclusions/interpretation DHEA serum levels might be an independent marker of type 2 diabetes. Electronic supplementary material The online version of this article (doi:10.1007/s00125-016-4136-8) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
Databáze: OpenAIRE
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