Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study
Autor: | Taulant Muka, Adela Brahimaj, Oscar H. Franco, Joop S.E. Laven, Abbas Dehghan, Maryam Kavousi |
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Přispěvatelé: | Epidemiology, Obstetrics & Gynecology |
Rok vydání: | 2016 |
Předmět: |
Male
Endocrinology Diabetes and Metabolism DHEA sulphate Type 2 diabetes Cohort Studies Rotterdam Study 0302 clinical medicine Risk Factors Sex Hormone-Binding Globulin 1114 Paediatrics And Reproductive Medicine polycyclic compounds Medicine Testosterone 030212 general & internal medicine DHEA skin and connective tissue diseases INSULIN SENSITIVITY Dehydroepiandrosterone Sulfate POLYCYSTIC-OVARY-SYNDROME Middle Aged POSTMENOPAUSAL WOMEN 1117 Public Health And Health Services Female Life Sciences & Biomedicine hormones hormone substitutes and hormone antagonists endocrine system medicine.medical_specialty SEX-DIFFERENCES DHEAS Food supplement ELDERLY-MEN Dehydroepiandrosterone 030209 endocrinology & metabolism Carbohydrate metabolism Lower risk Article Endocrinology & Metabolism 03 medical and health sciences SDG 3 - Good Health and Well-being Internal medicine Internal Medicine Humans Androstenedione ADVANCING AGE Aged Science & Technology business.industry GLUCOSE-UPTAKE DEHYDROISOANDROSTERONE SULFATE 1103 Clinical Sciences Human physiology medicine.disease Endocrinology Diabetes Mellitus Type 2 SULFATE CONCENTRATIONS Independent marker business human activities |
Zdroj: | Diabetologia Diabetologia, 60(1), 98-106. Springer-Verlag |
ISSN: | 1432-0428 0012-186X |
Popis: | Aims/hypothesis Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. Methods We used data on serum levels of DHEA, DHEAS and androstenedione from 5189 middle-aged and elderly men and women from the prospective population-based Rotterdam Study. Type 2 diabetes was defined as a fasting blood glucose ≥7.0 mmol/l or a non-fasting blood glucose ≥11.1 mmol/l. Results During a median follow-up of 10.9 years, 643 patients with incident type 2 diabetes were identified. After adjusting for age, sex, cohort, fasting status, fasting glucose and insulin, and BMI, both serum DHEA levels (per 1 unit natural log-transformed, HR 0.76, 95% CI 0.67, 0.87) and serum DHEAS levels (per 1 unit natural log-transformed, HR 0.82, 95% CI 0.73, 0.92) were inversely associated with risk of type 2 diabetes in the total population. Further adjustment for alcohol, smoking, physical activity, prevalent cardiovascular disease, serum total cholesterol, use of lipid-lowering medications, systolic BP, treatment for hypertension, C-reactive protein, oestradiol and testosterone did not substantially affect the association between DHEA and incident type 2 diabetes (per 1 unit natural log-transformed, HR 0.80, 95% CI 0.65, 0.99), but abolished the association between DHEAS and type 2 diabetes. Androstenedione was not associated with risk of type 2 diabetes, nor was DHEAS to DHEA ratio. Conclusions/interpretation DHEA serum levels might be an independent marker of type 2 diabetes. Electronic supplementary material The online version of this article (doi:10.1007/s00125-016-4136-8) contains peer-reviewed but unedited supplementary material, which is available to authorised users. |
Databáze: | OpenAIRE |
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