Continuous flow synthesis of some 6-and 1,6-substituted 3-cyano-4-methyl-2-pyridones
| Autor: | Julijana Tadić, Dusan Z. Mijin, Marina Mihajlović, Mića Jovanović |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Continuous flow flow synthesis General Chemistry 010402 general chemistry microreactor 01 natural sciences Spectral line 0104 chemical sciences Volumetric flow rate lcsh:Chemistry 2-Pyridone batch chemistry.chemical_compound lcsh:QD1-999 chemistry Chemical engineering Yield (chemistry) 2-pyridone Melting point Molecule process intensification Microreactor |
| Zdroj: | Journal of the Serbian Chemical Society Journal of the Serbian Chemical Society, Vol 84, Iss 6, Pp 531-538 (2019) |
| Popis: | In this study, six 6- and 1,6-substituted-3-cyano-4-methyl-2-pyridones were synthesized in a continuous flow microreactor system. The syntheses were realized at room temperature and the obtained results were compared to those achieved within classical syntheses. In order to optimize the continuous flow syntheses and increase the yield of the products, the retention time in the microreactor was varied by changing the flow rates of the reactant solutions. Furthermore, the reaction was optimized for 3-cyano-4,6-dimethyl-2- -pyridone and 3-cyano-6-hydroxy-4-methyl-2-pyridone, which are comercially important in the pharmaceutical and dye industries. Both 2-pyridones were obtained in satisfactory yield of circa 60 % in less than 10 min. The resulting compounds were characterized by their melting points, FT-IR, 1H-NMR and UV–Vis spectra. The efficiency of the presented method for the synthesis of 2-pyridone-based molecules has promising potential for industrial production. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. OI172013 and Grant no. TR34009] |
| Databáze: | OpenAIRE |
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