The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer’s Disease
| Autor: | Anshi Wu, Fan Ye |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
03 medical and health sciences 0302 clinical medicine Sirtuin 1 Alzheimer Disease Autophagy Animals Humans Nuclear protein Transcription factor Neurons Organelle Biogenesis biology Mechanism (biology) General Neuroscience General Medicine Peroxisome Mitochondria Cell biology Psychiatry and Mental health Clinical Psychology 030104 developmental biology Histone Gene Expression Regulation Mitochondrial biogenesis Acetylation biology.protein Geriatrics and Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 82:149-157 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Silent information-regulated transcription factor 1 (SIRT1) is the most prominent and widely studied member of the sirtuins (a family of mammalian class III histone deacetylases). It is a nuclear protein, and the deacetylation of the peroxisome proliferator-activated receptor coactivator-1 has been extensively implicated in metabolic control and mitochondrial biogenesis and is the basis for studies into its involvement in caloric restriction and its effects on lifespan. The present study discusses the potentially protective mechanism of SIRT1 in the regulation of the mitochondrial biogenesis and autophagy involved in the modulation of Alzheimer’s disease, which may be correlated with the role of SIRT1 in affecting neuronal morphology, learning, and memory during development; regulating metabolism; counteracting stress responses; and maintaining genomic stability. Drugs that activate SIRT1 may offer a promising approach to treating Alzheimer’s disease. |
| Databáze: | OpenAIRE |
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