Antioxidant Capacity, Anticancer Ability and Flavonoids Composition of 35 Citrus (Citrus reticulata Blanco) Varieties

Autor: Jinping Cao, Dengliang Wang, Rongxi Yang, Chunrong Liu, Jing Qian, Yue Wang, Xian Li, Chongde Sun
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Citrus
Spectrometry
Mass
Electrospray Ionization
Antioxidant
Oxygen radical absorbance capacity
DPPH
Cell Survival
medicine.medical_treatment
Flavonoid
Pharmaceutical Science
Flavones
Article
Antioxidants
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
0404 agricultural biotechnology
Phenols
lcsh:Organic chemistry
Chromatography detector
Stomach Neoplasms
Cell Line
Tumor
Drug Discovery
phenolics contents
medicine
Humans
Food science
Physical and Theoretical Chemistry
Chromatography
High Pressure Liquid
chemistry.chemical_classification
Flavonoids
Plant Extracts
Organic Chemistry
food and beverages
04 agricultural and veterinary sciences
antioxidant capacities
040401 food science
Antineoplastic Agents
Phytogenic
anticancer abilities
Biochemistry
chemistry
Chemistry (miscellaneous)
Flavanones
Molecular Medicine
Composition (visual arts)
flavonoids composition
Citrus reticulata
Zdroj: Molecules, Vol 22, Iss 7, p 1114 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 7; Pages: 1114
ISSN: 1420-3049
Popis: Citrus (Citrus reticulate Blanco) is one of the most commonly consumed and widely distributed fruit in the world, which is possessing extensive bioactivities. Present study aimed to fully understand the flavonoids compositions, antioxidant capacities and in vitro anticancer abilities of different citrus resources. Citrus fruits of 35 varieties belonging to 5 types (pummelos, oranges, tangerines, mandarins and hybrids) were collected. Combining li quid chromatography combined with electrospray ionization mass spectrometry (LC-ESI-MS/MS) and ultra-performance liquid chromatography combined with diode array detector (UPLC-DAD), a total of 39 flavonoid compounds were identified, including 4 flavones, 9 flavanones and 26 polymethoxylated flavonoids (PMFs). Each citrus fruit was examined and compared by 4 parts, flavedo, albedo, segment membrane and juice sacs. The juice sacs had the lowest total phenolics, following by the segment membrane. Four antioxidant traits including 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC) and cupric reducing antioxidant capacity (CUPRAC) were applied for the antioxidant capacities evaluation. Three gastric cancer cell lines, SGC-7901, BGC-823 and AGS were applied for the cytotoxicity evaluation. According to the results of correlation analysis, phenolics compounds might be the main contributor to the antioxidant activity of citrus extracts, while PMFs existing only in the flavedo might be closely related to the gastric cancer cell line cytotoxicity of citrus extracts. The results of present study might provide a theoretical guidance for the utilization of citrus resources.
Databáze: OpenAIRE
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