Slow viral dynamics of hepatitis C virus genotype 4
| Autor: | Hacène Khiri, A Rieu, Philippe Halfon, Denis Ouzan, Avidan U. Neumann, Patrice Cacoub, S Chadapaud, Marc Bourlière |
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| Rok vydání: | 2003 |
| Předmět: |
Time Factors
viruses Hepatitis C virus Alpha interferon Hepacivirus Biology medicine.disease_cause Antiviral Agents law.invention Pharmacotherapy law Virology Hepatitis C virus genotype Ribavirin Genotype medicine Humans Hepatology virus diseases Hepatitis C Hepatitis C Chronic Viral Load medicine.disease Recombinant Proteins digestive system diseases Treatment Outcome Infectious Diseases Interferon Type I Immunology Recombinant DNA Drug Therapy Combination Viral load |
| Zdroj: | Journal of Viral Hepatitis. 10:351-353 |
| ISSN: | 1365-2893 1352-0504 |
| DOI: | 10.1046/j.1365-2893.2003.00433.x |
| Popis: | Patients infected with hepatitis C virus genotype 4 (HCV-4) respond to interferon alpha (IFN) as poorly as those infected with genotype 1. However, there is no information on the viral dynamics of HCV-4. Interferon-ribavirin treatment was administered to untreated patients infected with HCV-4. Viral load was assessed with Versant 3.0. Viral dynamics parameters were estimated based on the bi-phasic model for HCV during IFN treatment. Viral kinetics of HCV-4 follow a bi-phasic decline pattern also. The mean effectiveness of IFN in blocking production of HCV-4 was a decline of 77.8% during the first day of treatment. The half-life of free virions was estimated at 3.5 h and that of infected cells from 1.9 to over 70 days. The viral dynamics parameters of HCV-4 appear similar to those of HCV-1 and slower than those of HCV-2. HCV-4 infected patients should be grouped with those with HCV-1 when therapeutic schemes are considered in relation to genotype. |
| Databáze: | OpenAIRE |
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