Anticarcinogenic and Antioxidant Action of an Edible Aquatic Flora
| Autor: | Asem Kajal Devi, Susheel Kumar Sharma, Pangambam Langamba, Heikham Naresh Singh, Thangjam Surchandra Singh, Haobijam Sanjita Devi, Elangbam Diana Devi, Pintubala Kshetri, K. Tamreihao, Chongtham Sonia, Chongtham Rajiv, Romila Akoijam, Meraj Alam Ansari, S. S. Roy, Chongtham Tania |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
PANC-1 Antioxidant DPPH medicine.medical_treatment MDA-MB-231 Pharmaceutical Science antioxidant activity SKOV3 antiproliferative properties Pharmacology medicine.disease_cause Antioxidants Analytical Chemistry HeLa chemistry.chemical_compound 0302 clinical medicine PC3 Drug Discovery Zebrafish ABTS biology Chemistry (miscellaneous) 030220 oncology & carcinogenesis PC-3 Cells Molecular Medicine Biological Assay Oxidation-Reduction Jussiaea repens L Antineoplastic Agents anticancer Article lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry In vivo Cell Line Tumor medicine Animals Humans Physical and Theoretical Chemistry Organic Chemistry biology.organism_classification 030104 developmental biology chemistry Polyphenol Oxidative stress HeLa Cells |
| Zdroj: | Molecules Volume 26 Issue 8 Molecules, Vol 26, Iss 2291, p 2291 (2021) |
| ISSN: | 1420-3049 |
| Popis: | Oxidative stress is the major cause of many health conditions, and regular consumption of antioxidants helped to encounter and prevent such oxidative stress-related diseases. Due to safety concerns over long-term uses of synthetic antioxidants, natural antioxidants are more preferred. The purpose of this study is to investigate the antioxidant and anticancer activities of Jussiaea repens L., a wild edible flora found in Manipur, India. The antioxidant activity was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), Ferric reducing antioxidant power (FRAP) assay and DNA-nicking assay. The anticancer activity was tested using five cancer lines viz., SKOV3 cells (ovarian), HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and PC3 (prostate). The toxicity, developmental effect, antiproliferative activity was further tested using zebrafish embryos. The methanolic plant extract had higher polyphenol content than flavonoids. The in vitro study demonstrated a promising antioxidant capacity and DNA protection ability of this plant. The extract also showed cytotoxic activity against SKOV3, HeLa, MDA-MB-23, and PANC-1 cancer cell lines. The in vivo studies on zebrafish embryos demonstrated the extract’s ability to suppress the developmental process and elicited more cytotoxicity to cancer cells than developing zebrafish embryos. Moreover, the in vivo studies on zebrafish embryos also indicated the antiproliferative activity of J. repens L. extract. |
| Databáze: | OpenAIRE |
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