FMR1 alleles in Parkinson's disease: relation to cognitive decline and hallucinations, a longitudinal study

Autor: Thomas Mueller, Yvonne Klenk, Jan Petter Larsen, Gabriele Dekomien, Dag Aarsland, Anna Melissa Schlitter, Martin Wilhelm Kurz
Rok vydání: 2007
Předmět:
0301 basic medicine
Adult
Male
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Parkinson's disease
Hallucinations
DNA Mutational Analysis
Statistics as Topic
Neuropsychological Tests
03 medical and health sciences
Fragile X Mental Retardation Protein
0302 clinical medicine
Degenerative disease
Trinucleotide Repeats
Internal medicine
medicine
Dementia
Humans
Longitudinal Studies
Cognitive decline
Psychiatry
Alleles
Aged
Neurologic Examination
Parkinsonism
Genetic Carrier Screening
Cognitive disorder
Parkinson Disease
Middle Aged
medicine.disease
FMR1
nervous system diseases
Fragile X syndrome
Psychiatry and Mental health
030104 developmental biology
Endocrinology
030220 oncology & carcinogenesis
Neurology (clinical)
Geriatrics and Gerontology
Psychology
Cognition Disorders
Mental Status Schedule
Zdroj: Journal of geriatric psychiatry and neurology. 20(2)
ISSN: 0891-9887
Popis: Carriers of expanded alleles of the fragile X mental retardation ( FMR1) gene may display parkinsonism, cognitive decline, and behavioral changes. The authors screened 2 male groups of patients affected with Parkinson's disease (PD) (n = 137). One group (n = 56) was followed longitudinally for up to 12 years. Length of CGG repeats in PD patients was compared with healthy controls (n = 310). In addition, the association of the number of CGG repeats with cognitive decline or hallucinations was studied in the longitudinally followed PD group. The authors found no repeats in the premutation range (55-200 CGG repeats) and no significant difference in the proportion of intermediate-size (41-54 CGG repeats) carriers between the PD and the control groups. Using linear regression, the number of CGG repeats was not related to motor or cognitive progression. However, the marked cognitive decline in 2 patients carrying intermediate-size alleles points to a possible association. More studies with larger PD samples are warranted. ( J Geriatr Psychiatry Neurol 2007;20:89-92)
Databáze: OpenAIRE
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