Ketamine-dependent neuronal activation in healthy volunteers
| Autor: | Marie Spies, Thomas Vanicek, Sebastian Ganger, Georg S. Kranz, Christian Windischberger, Andreas Hahn, Siegfried Kasper, Martin Küblböck, Dietmar Winkler, Rupert Lanzenberger, Anna Höflich |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Histology Rest Thalamus Placebo Brain mapping Young Adult 03 medical and health sciences 0302 clinical medicine Double-Blind Method Image Processing Computer-Assisted medicine Humans Ketamine Anterior cingulate cortex Psychiatric Status Rating Scales Analysis of Variance Brain Mapping General Neuroscience Brain Magnetic Resonance Imaging Healthy Volunteers 030227 psychiatry Oxygen Esketamine medicine.anatomical_structure Anesthesia Female Orbitofrontal cortex Anatomy Psychology Excitatory Amino Acid Antagonists Insula Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brain Structure and Function. 222:1533-1542 |
| ISSN: | 1863-2661 1863-2653 |
| Popis: | Over the last years, a number of studies have been conducted to clarify the neurobiological correlates of ketamine application. However, comprehensive information regarding the influence of ketamine on cortical activity is still lacking. Using resting-state functional MRI and integrating pharmacokinetic information, a double-blind, randomized, placebo-controlled, crossover study was performed to determine the effects of ketamine on neuronal activation. During a 55 min resting-state fMRI scan, esketamine (Ketanest S®) was administered intravenously to 35 healthy volunteers. Neural activation as indicated by the BOLD signal using the pharmacokinetic curve of ketamine plasma levels as a regressor was computed. Compared with placebo, ketamine-dependent increases of neural activation were observed in the midcingulate cortex, the dorsal part of the anterior cingulate cortex, the insula bilaterally, and the thalamus (t values ranging between 5.95-9.78, p |
| Databáze: | OpenAIRE |
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