Cytotoxic Activity of Cunila angustifolia Essential Oil
| Autor: | Jessica Morgan, Karina Cesca, Neusa Fernandes de Moura, Matheus Henrique Oliveira de Sousa, Adriana Flach |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Cell Survival Bioengineering 01 natural sciences Biochemistry Gas Chromatography-Mass Spectrometry law.invention Terpene chemistry.chemical_compound food law Cell Line Tumor Oils Volatile Humans Food science Molecular Biology Essential oil A549 cell Cunila Lamiaceae 010405 organic chemistry General Chemistry General Medicine Menthone 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry chemistry Molecular Medicine Menthyl acetate Menthol Pulegone |
| Zdroj: | Chemistrybiodiversity. 17(2) |
| ISSN: | 1612-1880 |
| Popis: | The Cunila angustifolia essential oil was obtained from fresh leaves by hydrodistillation and analyzed by GC-FID and GC-MS to determine its chemical composition. The essential oil presented pulegone (29.5 %) and isomenthol (27.0 %) as major components, and other compounds such as menthone (8.6 %), neomenthol (7.2 %), menthyl acetate (2.5 %) and caryophyllene oxide (2.0 %) were identified. The cytotoxic activity of the essential oil was evaluated by MTS assay, with the human cancer cell lines of the lung (A549), breast (MCF-7) and skin melanoma (SK-Mel-28). The assay showed the highest selectivity, to MCF-7 cell lines, with IC50 equal to 34.0 μg mL-1 , low selectivity for SK-Mel-28 cell lines, with IC50 equal to 279.9 μg mL-1 , and no mortality to A549 cell lines. |
| Databáze: | OpenAIRE |
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