Adopting a High-Polyphenolic Diet Is Associated with an Improved Glucose Profile: Prospective Analysis within the PREDIMED-Plus Trial

Autor: Anna Tresserra-Rimbau, Sara Castro-Barquero, Nerea Becerra-Tomás, Nancy Babio, Miguel Ángel Martínez-González, Dolores Corella, Montserrat Fitó, Dora Romaguera, Jesús Vioque, Angel M. Alonso-Gomez, Julia Wärnberg, José Alfredo Martínez, Luís Serra-Majem, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, José López-Miranda, Naomi Cano-Ibáñez, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Lidia Daimiel, Vicente Martín Sánchez, Josep Vidal, Clotilde Vázquez, Emili Ros, Francisco Javier Basterra, María Fernández de la Puente, Eva M. Asensio, Olga Castañer, Vanessa Bullón-Vela, Lucas Tojal-Sierra, Enrique Gómez-Gracia, Eugenio Cases-Pérez, Jadwiga Konieczna, Antonio García-Ríos, Tamara Casañas-Quintana, María Rosa Bernal-Lopez, José Manuel Santos-Lozano, Virginia Esteve-Luque, Cristina Bouzas, Zenaida Vázquez-Ruiz, Antoni Palau-Galindo, Rocio Barragan, Mercè López Grau, Cristina Razquín, Leire Goicolea-Güemez, Estefanía Toledo, Manel Vila Vergaz, Rosa M. Lamuela-Raventós, Jordi Salas-Salvadó
Rok vydání: 2022
Předmět:
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
Antioxidants
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
Digibug. Repositorio Institucional de la Universidad de Granada
Antioxidants; Volume 11; Issue 2; Pages: 316
ISSN: 2076-3921
DOI: 10.3390/antiox11020316
Popis: We thank all PREDIMED-Plus participants and investigators. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of the Instituto de Salud Carlos III (ISCIII), Madrid, Spain. The Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) food companies donated extra-virgin olive oil. The Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Plus pilot study. A.T.-R. is a Serra-Hunter fellow. SCB thanks the Spanish Ministry of Science Innovation and Universities for the Formacion de Profesorado Universitario (FPU17/00785) contract.
Previous studies suggested that dietary polyphenols could reduce the incidence and complications of type-2 diabetes (T2D); although the evidence is still limited and inconsistent. This work analyzes whether changing to a diet with a higher polyphenolic content is associated with an improved glucose profile. At baseline, and at 1 year of follow-up visits, 5921 participants (mean age 65.0 +/- 4.9, 48.2% women) who had overweight/obesity and metabolic syndrome filled out a validated 143-item semi-quantitative food frequency questionnaire (FFQ), from which polyphenol intakes were calculated. Energy-adjusted total polyphenols and subclasses were categorized in tertiles of changes. Linear mixed-effect models with random intercepts (the recruitment centers) were used to assess associations between changes in polyphenol subclasses intake and 1-year plasma glucose or glycosylated hemoglobin (HbA1c) levels. Increments in total polyphenol intake and some classes were inversely associated with better glucose levels and HbA1c after one year of follow-up. These associations were modified when the analyses were run considering diabetes status separately. To our knowledge, this is the first study to assess the relationship between changes in the intake of all polyphenolic groups and T2D-related parameters in a senior population with T2D or at high-risk of developing T2D.
Spanish Government FPU17/00785
Databáze: OpenAIRE
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