Bile is an important route of elimination of ingested aluminum by conscious male Sprague-Dawley rats
| Autor: | Janet L. Greger, Gwendolyn M. Radzanowski, Jessica E. Sutherland |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
inorganic chemicals
Male medicine.medical_specialty medicine.drug_class Administration Oral Toxicology Body weight complex mixtures Bile Acids and Salts Rats Sprague-Dawley Oral administration Internal medicine medicine Sprague dawley rats Toxicokinetics Animals Bile Tissue Distribution Bile acid Chemistry Aluminum lactate Light metal Rats Endocrinology Liver Excretory system Regression Analysis Aluminum |
| Zdroj: | Toxicology. 109(2-3) |
| ISSN: | 0300-483X |
| Popis: | We assessed the importance of bile as an excretory route for ingested aluminum (Al). Bile ducts in 30 male Sprague-Dawley rats were cannulated to allow both bile collection and reinfusion of bile acids. Five days after surgery, rats (average weight = 191 ± 4 g) were given a single oral dose of aluminum (0, 0.2, 0.4, or 0.8 mmol) as aluminum lactate in 1 ml of 16% citrate by gavage. Bile was collected 1–7 h after dosing from unanesthetized rats. Biliary aluminum secretion was highest during the first hour of bile collection. All rats dosed with aluminum secreted significantly greater amounts of aluminum in bile than control rats. However, biliary aluminum secretion did not vary among animals given the different aluminum doses suggesting that biliary secretion of aluminum was saturated at these doses. Rats dosed with 0.8 mmol Al retained significantly greater amounts of aluminum in soft tissues than those given 0.2 or 0.4 mmol Al. This result suggests that physiological mechanisms were unable to prevent tissue aluminum accumulation in the rats given the highest dose. |
| Databáze: | OpenAIRE |
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