Retinal and Choriocapillaris Vascular Changes in Patients Affected by Different Clinical Phenotypes of β-Thalassemia: An Optical Coherence Tomography Angiography Study
| Autor: | Michela Grosso, Daniela Montorio, Giuliano Mazzella, Gilda Cennamo, Maria Rosaria Storino, Aldo Filosa, Anna Spasiano, Paolo Ricchi, Silvia Costantini, Fausto Tranfa, Francesca Aquila |
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| Přispěvatelé: | Cennamo, G., Montorio, D., Mazzella, G., Ricchi, P., Costantini, S., Spasiano, A., Filosa, A., Storino, M. R., Aquila, F., Tranfa, F., Grosso, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Thalassemia Biology optical coherence tomography angiography General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology hemic and lymphatic diseases vessel density medicine Transfusion dependent thalassemia In patient lcsh:QH301-705.5 thalassemia minor General Immunology and Microbiology Retinal non transfusion dependent thalassemia Optical coherence tomography angiography medicine.disease Phenotype transfusion dependent thalassemia 030104 developmental biology spectral domain optical coherence tomography lcsh:Biology (General) chemistry 030221 ophthalmology & optometry Hemoglobin sense organs General Agricultural and Biological Sciences Perfusion |
| Zdroj: | Biology Volume 10 Issue 4 Biology, Vol 10, Iss 276, p 276 (2021) |
| ISSN: | 2079-7737 |
| DOI: | 10.3390/biology10040276 |
| Popis: | In this cross-sectional study we assessed the vascular alterations in retinal and choriocapillaris perfusion in patients affected by β-thalassemia, by means of optical coherence tomography angiography (OCTA). A total of 124 eyes of 62 patients (mean age 44.74 ± 5.79 years old) affected by β-thalassemia (transfusion dependent thalassemia (TDT), non-transfusion dependent thalassemia (NTDT) and minor) were compared to 40 eyes of twenty healthy subjects. We evaluated the vessel density (VD) in superficial capillary plexus, deep capillary plexus, radial peripapillary capillary, choriocapillaris and the foveal avascular zone area. The TDT group showed a statistically significant reduction in retinal and choriocapillaris VD respect to controls and the other groups (p < 0.05). No statistically significant difference was found in OCTA parameters between β-thalassemia minor and controls. The NTDT group showed a significant reduction in VD in deep capillary plexus respect to controls and β-thalassemia minor. Significant negative correlations were shown in TDT group between foveal avascular zone and hemoglobin (r = −0.437, p = 0.044) and between ferritin levels and VD of choriocapillaris (r = −0.431, p = 0.038). The OCTA parameters provided a deeper understanding on retinal and choriocapillaris vascular impairment affected by tissue hypoxia levels and the oxidative stress in different clinical phenotypes of the β-thalassemia. |
| Databáze: | OpenAIRE |
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