High rates of advanced prostate cancer in the Middle East: Analysis from a tertiary care center

Autor: Wassim Wazzan, Alissar El Chediak, Sally Temraz, Muhammad Bulbul, Marilyne Daher, Raja B. Khauli, Sarah Abdel Massih, Rami Nasr, Ali Shamseddine, Maya Charafeddine, Christelle Dagher, Talar Telvizian, Raafat Alameddine, Deborah Mukherji, Fady Geara, Bassem Youssef, Albert El Hajj, Mohammed Shahait, Zahi Abdul-Sater
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Urology Annals
Urology Annals, Vol 13, Iss 4, Pp 418-423 (2021)
ISSN: 0974-7834
0974-7796
Popis: Objectives: Prostate cancer incidence is increasing in the Middle East (ME); however, the data of stage at the diagnosis and treatment outcomes are lacking. In developed countries, the incidence of de novo metastatic prostate cancer ranges between 4% and 14%. We hypothesized that the rates of presentation with advanced disease are significantly higher in the ME based on clinical observation. This study aims to examine the stage at the presentation of patients with prostate cancer at a large tertiary center in the ME. Methods: After Institutional Review Board approval, we identified the patients diagnosed with prostate adenocarcinoma and presented to a tertiary care center between January 2010 and July 2015. Clinical, demographic, and pathological characteristics were abstracted. Patients with advanced disease were stratified according to tumor volume based on definitions from practice changing clinical trials. Descriptive and Kaplan–Meier survival analysis was used. Results: A total of 559 patients were identified, with a median age at the diagnosis of 65 years and an age range of 39–94 years. Median prostate-specific antigen (PSA) at the presentation was 10 ng/ml, and almost a quarter of the men (23%) presented with metastatic disease. The most common site of metastasis was the bone (34/89, 38%). High-volume metastasis was present in 30.3%, 9%, and 5.2% of the cohort based on STAMPEDE, CHAARTED, and LATITUDE trial criteria, respectively. Conclusion: This is the first report showing the high proportion of men from ME presenting with de novo metastasis. This could be due to many factors, including the highly variable access to specialist multidisciplinary management, lack of awareness, and lack of PSA screening in the region. There is a clear need to raise the awareness about prostate cancer screening and early detection and to address the rising burden of advanced prostate cancer affecting men in the ME region.
Databáze: OpenAIRE
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