Hypoxia-Overcoming Breast-Conserving Treatment by Magnetothermodynamic Implant for a Localized Free-Radical Burst Combined with Hyperthermia
| Autor: | Jing Yu, Xiaoxiao Guo, Shenglei Che, Xiumei Wang, Yongjie Chi, Jingsong Lu, Lingyun Zhao, Wanling Xu, Benhua Xu, Jielin Ye, Xiaohan Gao, Wensheng Xie, Zhenhu Guo, Rong Zheng, Xiaodan Sun |
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| Rok vydání: | 2021 |
| Předmět: |
Hyperthermia
Materials science Alginates Antineoplastic Agents Breast Neoplasms chemistry.chemical_compound Breast cancer Cell Line Tumor medicine Animals General Materials Science Mice Inbred BALB C Tumor hypoxia Magnetic Phenomena Imidazoles Cancer Hydrogels Hyperthermia Induced Hypoxia (medical) medicine.disease Magnetic hyperthermia chemistry Cancer research Female Magnetic Iron Oxide Nanoparticles Implant medicine.symptom Reactive Oxygen Species Azo Compounds Iron oxide nanoparticles |
| Zdroj: | ACS Applied Materials & Interfaces. 13:35484-35493 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.1c09355 |
| Popis: | For the purpose of improving the quality of life and minimizing the psychological morbidity of a mastectomy, breast-conserving treatment (BCT) has become the more preferable choice in breast cancer patients. Meanwhile, tumor hypoxia has been increasingly recognized as a major deleterious factor in cancer therapies. In the current study, a novel, effective, and noninvasive magnetothermodynamic strategy based on an oxygen-independent free-radical burst for hypoxia-overcoming BCT is proposed. Radical precursor (AIPH) and iron oxide nanoparticles (IONPs) are coincorporated within the alginate (ALG) hydrogel, which is formed in situ within the tumor tissue by leveraging the cross-linking effect induced by the local physiological Ca2+ with ALG solution. Inductive heating is mediated by IONPs under AMF exposure, and consequently, regardless of the tumor hypoxia condition, a local free-radical burst is achieved by thermal decomposition of AIPH via AMF responsivity. The combination of magnetic hyperthermia and oxygen-irrelevant free-radical production effectively enhances the in vitro cytotoxic effect and also remarkably inhibits tumor proliferation. This study provides a valuable protocol for an hypoxia-overcoming strategy and also an alternative formulation candidate for noninvasive BCT. |
| Databáze: | OpenAIRE |
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