Fibroblasts as efficient antigen-presenting cells in lymphoid organs
| Autor: | Manuel Battegay, Rolf M. Zinkernagel, Heinz Lother, John J.L. Simard, Thomas M. Kündig, Martin F. Bachmann, Klaus Kühlcke, Claudio Dipaolo, André Gessner, Hans Hengartner, Pamela S. Ohashi |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Cytotoxicity
Immunologic Cellular immunity Lymphoid Tissue Antigen presentation Antigen-Presenting Cells Biology Lymphocytic Choriomeningitis Transfection Mice Viral Proteins Immune system L Cells Antigen Neoplasms Tumor Cells Cultured Cytotoxic T cell Animals Lymphocytic choriomeningitis virus Antigen-presenting cell Glycoproteins Multidisciplinary Histocompatibility Antigens Class I T lymphocyte Fibroblasts Mice Inbred C57BL Immunology Cancer research T-Lymphocytes Cytotoxic |
| Zdroj: | Science (New York, N.Y.). 268(5215) |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies. |
| Databáze: | OpenAIRE |
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