Assessment of bioavailability of experimental single-unit sustained release tablets of verapamil hydrochloride using the stable isotope technique
| Autor: | Anneli Kannikoski, Jyrki Taskinen, Martti Marvola, Pekka Ottoila |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Biological Availability Pharmaceutical Science 02 engineering and technology Absorption (skin) Pharmacology 030226 pharmacology & pharmacy Gas Chromatography-Mass Spectrometry Dosage form Absorption Delayed-Action Preparations 03 medical and health sciences Verapamil Hydrochloride 0302 clinical medicine medicine Humans Solubility Chromatography Chemistry Half-life 021001 nanoscience & nanotechnology 3. Good health Bioavailability Kinetics Verapamil Female Tablets Enteric-Coated 0210 nano-technology Half-Life medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 37:766-770 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1985.tb04965.x |
| Popis: | A stable isotope technique has been used to assess the bioavailability of sustained release verapamil products. The test formulations were tablets with a core containing 90 mg of verapamil hydrochloride coated with ethylcellulose film, the permeability of which was controlled using different amounts of hydroxypropyl methylcellulose. A product containing ethylcellulose 75% hydroxypropyl methylcellulose 25% w/w gave a single-unit sustained release tablet of verapamil hydrochloride that allowed a dose interval of 24 h. There was no loss in bioavailability, even though verapamil had extensive first-pass metabolism. |
| Databáze: | OpenAIRE |
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