Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin
| Autor: | K.B. Mathur, Anil K. Rastogi, Nafees Ahmad, Shubh D. Sharma, Jalil R. Kidwai |
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| Rok vydání: | 1984 |
| Předmět: |
Endocrinology
Diabetes and Metabolism medicine.medical_treatment Stimulation digestive system Tetragastrin Islets of Langerhans Residue (chemistry) chemistry.chemical_compound Endocrinology Amide Gastrins Insulin Secretion Internal Medicine medicine Animals Insulin Insulin secretion Cholecystokinin C-Peptide Tetrapeptide Chemistry digestive oral and skin physiology Biological activity General Medicine Stimulation Chemical Rats Biochemistry hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Diabetologica Latina. 21:361-364 |
| ISSN: | 1432-5233 0001-5563 |
| DOI: | 10.1007/bf02582090 |
| Popis: | Two tetrapeptides, Glp-Met-Asp-Phe-NH2 (I) and Pro-Met-Asp-Phe-NH2 (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10(-8) M and 10(-6) M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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