Chromosomal mapping in the mouse of eight K + -channel-genes representing the four Shaker -like subfamilies Shaker, Shab, Shaw , and Shal
| Autor: | Harald Jockusch, Steven L. Roberds, Monika Gronemeier, Barbara Albrecht, Michael M. Tamkun, Olaf Pongs, Rainer Klocke, André Augustin |
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| Rok vydání: | 1993 |
| Předmět: |
Genetics
Potassium Channels Mus spretus Restriction Mapping Chromosome Mapping Mice Inbred Strains Biology biology.organism_classification Muridae Mice Gene mapping Chromosome 3 Multigene Family Animals Chromosomes Human Humans Drosophila Shaker DNA Probes Gene Crosses Genetic Polymorphism Restriction Fragment Length K channels |
| Zdroj: | Genomics. 18:568-574 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/s0888-7543(05)80358-1 |
| Popis: | The four Shaker -like subfamilies of Shaker-, Shab-,Shaw- , and Shal -related K + channels in mammals have been defined on the basis of their sequence homologies to the corresponding Drosophila genes. Using interspecific backcrosses between Mus musculus and Mus spretus , we have chromosomally mapped in the mouse the Shaker -related K + -channel genes Kcna1, Kcna2, Kcna4, Kcna5 , and Kcna6 ; the Shab -related gene Kcnb1 ; the Shaw -related gene Kcnc4 ; and the Shal -related gene Kcnd2 . The following localizations were determined: Chr 2, cen- Acra-Kcna4-Pax-6-a-Pck-1-Kras-3-Kcnb1 (corresponding human Chrs 11p and 20q, respectively); Chr 3, cen- Hao-2-(Kcna2, Kcnc4)-Amy-1 (human Chr 1); and Chr 6, cen- Cola-2-Met-Kcnd2-Cpa-Tcrb-adr/Clc-1-Hox-1.1-Myk-103-Raf-1-(Tpi-1, Kcna1, Kcna5, Kcna6 ) (human Chrs 7q and 12p, respectively). Thus, there is a cluster of at least three Shaker -related K + -channel genes on distal mouse Chr 6 and a cluster on Chr 2 that at least consists of one Shaker -related and one Shaw -related gene. The three other K + -channel genes are not linked to each other. The map positions of the different types of K + -channel genes in the mouse are discussed in relation to those of their homologs in man and to hereditary diseases of mouse and man that might involve K + channels. |
| Databáze: | OpenAIRE |
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