Case-control study of antenatal cocaine use and platelet levels
Autor: | Thomas E. Nolan, Joseph M. Miller |
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Rok vydání: | 2001 |
Předmět: |
Adult
medicine.medical_specialty Adolescent Urban Population Statistics Nonparametric Cocaine-Related Disorders symbols.namesake Cocaine Pregnancy Prevalence Humans Medicine Platelet Risk factor Poverty Fisher's exact test Marital Status Receiver operating characteristic Platelet Count business.industry Obstetrics Pregnancy Complications Hematologic Case-control study Obstetrics and Gynecology Gestational age medicine.disease Thrombocytopenia Surgery Parity ROC Curve Case-Control Studies symbols Marital status Female business |
Zdroj: | American Journal of Obstetrics and Gynecology. 184:434-437 |
ISSN: | 0002-9378 |
DOI: | 10.1067/mob.2001.110309 |
Popis: | Objective: Our aim was to determine the prevalence of thrombocytopenia in pregnant patients who did and did not use cocaine. Study Design: A 1:1 case-control study of 326 patients attending an inner-city, neighborhood-based antenatal program between January 1992 and December 1998 is presented. Data concerning cocaine use (history and urine toxicology study) and platelet count, along with gestational age, were compared by nonparametric techniques (χ 2 test, Fisher exact test, Wilcoxon rank sums, and receiver operating characteristic curve). Results: The prevalence of thrombocytopenia during pregnancy was not different between cocaine-using patients (13/160; 8.1%) and nonusing patients (11/160; 6.9%; difference not significant). In patients who abused cocaine and for whom both positive and negative urine screening results were obtained concomitantly with platelet levels, no difference in platelet counts was evident. Overall, thrombocytopenia occurred more often in the third trimester than earlier in pregnancy for both control and cocaine-using pregnant women. Conclusion: Cocaine use among pregnant women was not associated with thrombocytopenia. A low platelet count was found more often later in pregnancy. (Am J Obstet Gynecol 2001;184:434-7.) |
Databáze: | OpenAIRE |
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