Serum estradiol and progesterone in the mid-luteal phase predict clinical pregnancy outcome in IVF/ICSI cycles

Autor:	Ludwig Kiesel, Barbara Sonntag, Jerzy-Roch Nofer, Robert R. Greb, Kay C. Loebbecke
Rok vydání:	2013
Předmět:	medicine.medical_specialty Pregnancy Rate Endocrinology Diabetes and Metabolism medicine.medical_treatment Fertilization in Vitro Luteal Phase Luteal phase Sensitivity and Specificity Intracytoplasmic sperm injection Andrology Endocrinology Human fertilization Pregnancy medicine Humans Sperm Injections Intracytoplasmic Prospective cohort study Progesterone reproductive and urinary physiology Gynecology Estradiol urogenital system business.industry Pregnancy Outcome Obstetrics and Gynecology Ivf icsi Prognosis medicine.disease Embryo transfer Abortion Spontaneous Pregnancy rate Female business Infertility Female
Zdroj:	Gynecological Endocrinology. 29:700-703
ISSN:	1473-0766 0951-3590
Popis:	In this prospective study, we tested the hypothesis if E2 and P serum levels significantly differ during the luteal phase following in vitro-fertilization/intracytoplasmic sperm injection (IVF/ICSI) therapy in conception (CC) versus non-conception (NC) cycles, and their potential in the prediction of pregnancy at the earliest point in time. Serum was sampled from the day of embryo transfer (ET) and throughout the luteal phase until ET + 14 from patients consecutively enrolling for IVF/ICSI therapy. The luteal phase was supported by vaginal P suppositories only, clinical pregnancies were detected by ultrasound and followed up until the 20th week. Overall pregnancy rate was 30.9% constituting the two study groups of CC (n = 22) and NC cycles (n = 49). Significantly, higher E2 (3326 ± 804 versus 1072 ± 233 pmol/l, p = 0.014) and P (244 ± 68 versus 73 ± 10 nmol/l, p = 0.023) were present in CC versus NC from as early as ET + 7. In the CC group, patients with ongoing pregnancies (CC-OG) as compared with miscarriages (CC-MC) had significantly higher E2 and P from ET + 7, predicting ongoing pregnancy in receiver operator characteristics analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0cb8eacca4ae555239015ff22461c4 https://doi.org/10.3109/09513590.2013.797392 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.