Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver
Autor: | Franciszek Burdan, Z Siezieniewska, Z Urbanowicz |
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Rok vydání: | 2001 |
Předmět: |
medicine.medical_specialty
Pathology Bilirubin Health Toxicology and Mutagenesis H&E stain Toxicology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Liver Function Tests Pregnancy Caffeine Internal medicine medicine Animals Rats Wistar Acetaminophen medicine.diagnostic_test Anti-Inflammatory Agents Non-Steroidal Body Weight Organ Size General Medicine Analgesics Non-Narcotic Periodic Acid-Schiff Reaction Rats Drug Combinations Endocrinology Liver Toxic injury chemistry 030220 oncology & carcinogenesis Toxicity Urea Pregnancy Animal Central Nervous System Stimulants Female Chemical and Drug Induced Liver Injury Liver function tests Antipyrine medicine.drug |
Zdroj: | Human & Experimental Toxicology. 20:569-575 |
ISSN: | 1477-0903 0960-3271 |
Popis: | The common effects of acetaminophen (APA), isopropylantipyrine (IPA) and caffeine on liver were examined in rats. The preparations were given in Tween-80 solution once daily, in a constant proportion of 5:3:1, during days 8 to14 of gestation (S1, S2, S3 groups) or between days 8 and 14 of the experiment in nonpregnant female Wistar rats (S1-NP, S2-NP, S3-NP groups). The administration was in three different doses: doses S1, S1-NP — 3.5 mg/kg APA, 2.14 mg/ kg IPA, 0.7 mg/kg caffeine; doses S2, S2-NP were 10 times higher; and doses S3, S3-NP 100 times higher than doses S1, S1-NP. There were two control groups (T, T-NP) with Tween-80. At day 21 of gestation/experiment blood was taken for determination of activity of alanine (ALA) and aspartate (AST) aminotransferase, lactate (LDH) and glutamate (GLDH) dehydrogenase, levels of bilirubin (BIL), urea (URE), total protein (TP) and thymol turbidity test (TTT). The liver sections were examined by light microscopy with four stains: hematoxylin and eosin (H+E), silver Gomori, van Gieson and periodic acid-Schiff (PAS). There was a statistically significant (P |
Databáze: | OpenAIRE |
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