Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria
| Autor: | Warunee Hanpithakpong, François Nosten, Philip J. Rosenthal, N Jongrak, Noel Rouamba, Joel Tarning, Nicholas P. J. Day, Fabrice A. Somé, Niklas Lindegardh, J-B Ouedraogo, Issaka Zongo, Sunil Parikh, Nicholas J. White |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Article Pharmacotherapy Pharmacokinetics Internal medicine Piperaquine Burkina Faso parasitic diseases medicine Humans Pharmacology (medical) Malaria Falciparum Artemisinin Child Pharmacology business.industry Body Weight medicine.disease Artemisinins Regimen El Niño Child Preschool Pharmacodynamics Quinolines Drug Therapy Combination Female business Malaria medicine.drug |
| Zdroj: | Clinical Pharmacology & Therapeutics. 91:497-505 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.2011.254 |
| Popis: | Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They received a standard body weight-based oral 3-day fixed-dose dihydroartemisinin- piperaquine regimen. Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects modeling. The population pharmacokinetics of piperaquine were described accurately by a two-transit-compartment absorption model and a three-compartment distribution model. Body weight was a significant covariate affecting clearance and volume parameters. The individually predicted day 7 capillary plasma concentration of piperaquine was an important predictor (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text